Acne.org Products
Topical Antibacterial
Efficacy
54%
Based on All Available Studies
Strength of Evidence
Note: Benzoyl peroxide clears the skin completely when applied correctly.
Compare Treatments
Topical Antibacterial
Acne.org’s Real World Take
It’s been a staple of acne treatment for decades for a reason. When used properly it can completely clear the skin. It is widely available and affordable. Comes with side effects for the first few weeks and can bleach fabric.
Topical Antibacterial
How to Get It
This is an over-the-counter treatment. Here are some places you can find it online.
Topical Antibacterial
Acne.org’s Real World Take
At prescription strengths (15 - 20%) studies show it should help reduce mild-to-moderate acne by a significant and noticeable amount after 3 months or so of treatment, so that’s not too shabby. However, it is unlikely to completely clear the skin on its own.
Topical Antibacterial
How to Get It
Azelaic acid is available in 15% - 20% by prescription. Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one. Azelaic acid is also available over-the-counter in strengths 10% and lower. Here are some places you can find it online.
Phototherapy
Acne.org’s Real World Take
PDT as it’s called is an incredibly painful procedure, but one that may produce lasting results. It’s a less invasive option than isotretinoin for severe acne that doesn’t cause so many potentially lifelong side effects. However, it works by permanently disabling skin oil glands, and what happens long term when you do that remains unknown. Proceed with caution.
Phototherapy
How to Get It
Have a dermatologist? Make an appointment to get this procedure done. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Oral Retinoid
Efficacy
87%
Based on All Available Studies
Strength of Evidence
Note: Use with EXTREME CAUTION: Causes severe birth defects and fetal death.
Oral Retinoid
Acne.org’s Real World Take
The nuclear option. It works reliably and provides long-term remission of acne, and even severe acne, in about ⅔ of people who properly take an adequate dosage. However, it permanently and irreversibly changes the skin and the body forever and users may experience long-term side effects for the rest of their lives. It’ll nuke it, but there is no going back.
Oral Retinoid
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Retinoid
Acne.org’s Real World Take
Works about the same as the other two topical retinoids, tazarotene and adapalene, and lands in the middle of those two when it comes to side effects. Should provide partial clearing, but comes with sensitivity when you first start using it. It probably won’t be a total game changer but it should help reduce acne.
Topical Retinoid
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Retinoid
Acne.org’s Real World Take
This topical retinoid medication provides partial relief at higher prescription dosages, but don’t look for complete clearing. Relatively affordable and comes with less side effects than tretinoin, the other affordable topical retinoid. As a bonus, it improves the look of skin and reduces fine lines and wrinkles a bit too.
Topical Retinoid
How to Get It
Adapalene is available in strengths up to 0.3% by prescription. Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one. Adapalene is also available over-the-counter in 0.1% strength. Here are some places you can find it online.
Topical Retinoid
Acne.org’s Real World Take
Produces similar results to the two other topical retinoids, tretinoin and adapalene, which means only partial clearing, and comes with far more sensitivity and side effects when you first start using it. It probably won’t be a total game changer and don’t be surprised if it’s too much for your skin to take.
Topical Retinoid
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Retinoid
Acne.org’s Real World Take
Trifarotene is the newest retinoid to hit the market. It’s very expensive and not usually covered by insurance. It works in a slightly different way from the other retinoids (adapalene, tretinoin, tazarotene), and may provide slightly better results with a lesser chance of side effects. It should provide noticeable clearing of the skin, but is unlikely to completely clear you up on its own.
Topical Retinoid
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Retinoid / Topical Antibacterial
Efficacy
61%
Based on All Available Studies
Strength of Evidence
Topical Retinoid / Topical Antibacterial
Side Effects
Low-Medium
Topical Retinoid / Topical Antibacterial
Acne.org’s Real World Take
Similar to adapalene + benzoyl peroxide (Epiduo®), this is a way of using a topical retinoid (in this case tretinoin) along with benzoyl peroxide. However, studies thus far show very unimpressive results. Comes with side effects for the first weeks and can bleach fabric. Note: When used correctly, benzoyl peroxide on its own can completely clear the skin.
Topical Retinoid / Topical Antibacterial
Topical Retinoid / Topical Antibacterial
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Phototherapy
Acne.org’s Real World Take
Light therapy is a temporary and time-consuming treatment option that produces only modest results. However, it is the least invasive of any acne treatment, and its only downside is that it reduces folic acid levels.
Phototherapy
How to Get It
Light therapy can be performed with stronger, professional light devices at a doctor’s office. Have a dermatologist? Make an appointment to get this procedure done. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one. Weaker light therapy devices are also available over-the-counter. Here are some places you can find it online.
Hormonal Therapy
Efficacy
63%
Based on All Available Studies
Strength of Evidence
Note: Improvement significantly increases after 24 weeks.
Hormonal Therapy
Acne.org’s Real World Take
Any brand of oral contraceptive appears to clear the skin about the same amount, regardless of whether it is officially approved for acne treatment. Some people report complete clearing of acne symptoms and others see partial relief. However, artificially controlling your hormones is a serious decision, so it’s best to proceed with caution.
Hormonal Therapy
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Keratolytic
Acne.org’s Real World Take
Easy to find and with low side effects, but don’t be surprised if you are left wishing for better results after using it for a while. Any acid on its own is unlikely to dramatically clear acne.
Topical Keratolytic
How to Get It
This is an over-the-counter treatment. Here are some places you can find it online.
Chemical Exfoliation
Acne.org’s Real World Take
Common sense might tell us that chemical peels seem like such a great idea for acne, but in the real world, acid alone just doesn’t seem to completely take care of acne. They can also be expensive and leave the skin red and peeling for a few days every time you get one.
Chemical Exfoliation
How to Get It
Have a dermatologist? Make an appointment to get this procedure done. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one. Do not try this at home!
Phototherapy
Acne.org’s Real World Take
Laser therapy works by harming skin oil glands. That can lead to some improvement in acne, and perhaps even long-term relief of some acne symptoms. However, evolution gave us skin oil glands for a reason and what happens long term when you permanently disable them is still unknown. Proceed with caution.
Phototherapy
How to Get It
Have a dermatologist? Make an appointment to get this procedure done. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Antiandrogen
Acne.org’s Real World Take
“Spiro” has been shown to work in a real and noticeable way most of the time. However, messing with hormones is messing with hormones and it’s best to proceed with caution.
Antiandrogen
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Keratolytic
Acne.org’s Real World Take
Due to its antimicrobial properties and ability to absorb skin oil and dry out the skin, sulfur has been used for thousands of years for various skin conditions, including acne. However, it is normally reserved for noninflammatory acne (whiteheads and blackheads), because it doesn't work as well as other over-the-counter medications for inflammatory acne (papules and pustules).
Topical Keratolytic
How to Get It
This is an over-the-counter treatment. Here are some places you can find it online.
Topical Antibiotic / Topical Keratolytic
Efficacy
81%
Based on All Available Studies
Strength of Evidence
Topical Antibiotic / Topical Keratolytic
Acne.org’s Real World Take
Not often used because it smells bad, colors the skin when applied, and can (rarely) lead to severe side effects. Limited evidence shows that it does significantly clear mild-to-moderate acne, but we need more research to know for sure how well it works.
Topical Antibiotic / Topical Keratolytic
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Keratolytic / Topical Keratolytic
Acne.org’s Real World Take
Not often used because it smells bad, is opaque so it colors the skin when applied, and may rarely lead to severe side effects. Because of this, there haven’t been enough studies to show us whether it works or not, but it should help with mild-to-moderate acne.
Topical Keratolytic / Topical Keratolytic
How to Get It
This is an over-the-counter treatment. Here is a place you can find it online.
Topical Anti-inflammatory
Efficacy
53%
Based on All Available Studies
Strength of Evidence
Topical Anti-inflammatory
Acne.org’s Real World Take
An anti-inflammatory that takes weeks or months to kick in, so you’ll need patience. Provides modest benefit in some users. It’s never hit the big time in acne treatment. But it’s an interesting way to target acne on a purely inflammation level.
Topical Anti-inflammatory
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Retinoid / Topical Antibacterial
Efficacy
67%
Based on All Available Studies
Strength of Evidence
Topical Retinoid / Topical Antibacterial
Side Effects
Low-Medium
Topical Retinoid / Topical Antibacterial
Acne.org’s Real World Take
A way of using benzoyl peroxide in combination with the topical retinoid, adapalene, that studies show works a bit better than benzoyl peroxide alone. Comes with side effects for the first weeks and can bleach fabric. Note: When used correctly, benzoyl peroxide on its own can completely clear the skin.
Topical Retinoid / Topical Antibacterial
Reviews
Topical Retinoid / Topical Antibacterial
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Antibiotic / Topical Antibacterial
Efficacy
68%
Based on All Available Studies
Strength of Evidence
Topical Antibiotic / Topical Antibacterial
Acne.org’s Real World Take
A more dangerous way of using benzoyl peroxide that studies show works a bit better than benzoyl peroxide alone. However, when used properly, benzoyl peroxide on its own can completely clear the skin without the addition of antibiotics.
Topical Antibiotic / Topical Antibacterial
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Antibiotic / Topical Antibacterial
Efficacy
58%
Based on All Available Studies
Strength of Evidence
Topical Antibiotic / Topical Antibacterial
Side Effects
Low-Medium
Topical Antibiotic / Topical Antibacterial
Acne.org’s Real World Take
A more dangerous way of using benzoyl peroxide that studies show works a bit better than benzoyl peroxide alone. However, when used properly, benzoyl peroxide on its own can completely clear the skin without the addition of antibiotics.
Topical Antibiotic / Topical Antibacterial
Reviews
Topical Antibiotic / Topical Antibacterial
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Antibiotic
Efficacy
55%
Based on All Available Studies
Strength of Evidence
Note: Should never be used on its own and for a maximum of 3 months.
Topical Antibiotic
Acne.org’s Real World Take
One of the less effective treatments out there. It should never be used on its own or for longer than 3 months and may lead to resistant strains of bacteria. It may provide a slight improvement in mild acne in some people.
Topical Antibiotic
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Oral Antibiotic
Efficacy
54%
Based on All Available Studies
Strength of Evidence
Note: Should never be used on its own and for a maximum of 3 months.
Oral Antibiotic
Acne.org’s Real World Take
Antibiotics should be used for a maximum of 3 months, provide only moderate benefit and only to some people, and may lead to side effects and strains of resistant bacteria. Studies do show they can reduce severe acne in the short term, but approach with caution and stay your own advocate.
Oral Antibiotic
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Oral Antibiotic
Efficacy
69%
Based on All Available Studies
Strength of Evidence
Note: Should never be used on its own and for a maximum of 3 months.
Oral Antibiotic
Acne.org’s Real World Take
Antibiotics should be used for a maximum of 3 months, provide only moderate benefit to only some people, and may lead to side effects and strains of resistant bacteria. Studies do show they can sometimes reduce severe acne in the short term, but approach with caution and stay your own advocate.
Oral Antibiotic
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Oral Antibiotic
Efficacy
56%
Based on All Available Studies
Strength of Evidence
Note: Should never be used on its own and for a maximum of 3 months.
Oral Antibiotic
Acne.org’s Real World Take
Antibiotics should be used for a maximum of 3 months, provide only moderate benefit and only to some people, and may lead to side effects and strains of resistant bacteria. Studies do show doxycycline can reduce severe acne in the short term, and as far as oral antibiotics are concerned, it’s usually the go-to, but approach with caution and stay your own advocate.
Oral Antibiotic
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Oral Antibiotic
Acne.org’s Real World Take
Sarecycline is similar to other oral antibiotics prescribed for acne (doxycycline, minocycline, tetracycline) but is much more expensive, and based on studies thus far, works less well. Like other antibiotics, it should be used for a maximum of 3 months, provides only moderate benefit and only to some people, and may lead to side effects and strains of resistant bacteria.
Oral Antibiotic
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Antibiotic
Efficacy
52%
Based on All Available Studies
Strength of Evidence
Note: Should never be used on its own and for a maximum of 3 months.
Topical Antibiotic
Acne.org’s Real World Take
Antibiotics should be used for a maximum of 3 months, provide only moderate benefit and only to some people, and may lead to side effects and strains of resistant bacteria. Studies do show they can reduce severe acne in the short term, but approach with caution and stay your own advocate.
Topical Antibiotic
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Androgen Receptor Antagonist
Efficacy
46%
Based on All Available Studies
Strength of Evidence
Topical Androgen Receptor Antagonist
Acne.org’s Real World Take
It’s different from anything else because it targets male hormones in the skin, but it doesn’t seem to work all that well compared to other options. Plus, it’s good to have an eye out for new medications until they have been proven safe over many years. You can’t deny that it’s interesting though, and it might prove to be a nice tool alongside other meds.
Topical Androgen Receptor Antagonist
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Topical Minocycline Foam
Efficacy
52%
Based on All Available Studies
Strength of Evidence
Topical Minocycline Foam
Acne.org’s Real World Take
Topical minocycline is different from oral minocycline. You apply topical minocycline directly to the skin. It is similar to topical clindamycin, but is new on the market and much more expensive. It may also be slightly less effective. It should never be used on its own or for longer than 3 months and may lead to resistant strains of bacteria. It may provide a slight improvement in mild acne in some people
Topical Minocycline Foam
Topical Minocycline Foam
How to Get It
Have a dermatologist? Make an appointment to get this medication. Don't have a dermatologist? See The American Academy of Dermatology Physician Database to find one.
Thermotherapy
Acne.org’s Real World Take
Based on many people's experiences here on Acne.org, heat therapy doesn't seem to help whatsoever. In fact, it sometimes makes a lesion more noticeable. Most companies have stopped making the devices.
Thermotherapy
How to Get It
Manufacturers have largely stopped making these devices because they are ineffective. Buyer beware if you still find one anywhere!
Finding a Doctor
The right dermatologist can make a big difference to your patient experience and the success of your acne treatment plan. Here are the steps to find a dermatologist who is a good fit:
- Use the search feature on the American Academy of Dermatology website to look for board-certified dermatologists in your area, and filter the search results for doctors with a special interest in treating acne.
- Read online patient reviews of any dermatologists you are considering and ask people you know whether they have any experience with these dermatologists.
- Do your research and go to your first appointment with questions prepared.
- Listen to what your gut feeling tells you once you see a dermatologist in person. If you are not completely comfortable, try a different dermatologist.
Finding a Doctor
Only a select few plastic surgeons specialize in acne scar revision surgery. Be certain to find a provider who specializes in acne scar repair and who is passionate and experienced in this area.
Be sure to:
- Look at before and after photos, the more the better, especially patients with similar scarring to your own.
- Be realistic about results. Look for improvement, not a cure.
Questions to ask a potential scar revision specialist:
- Are you board certified? Be certain that they are board certified.
- How long have you been performing these procedures? Normally, the more experience the better, however, some younger surgeons may be more on top of the latest procedures.
- Can I speak to some of your other patients? Ask for references for several patients who had similar scarring and speak to them about the process and their satisfaction with results.
Red flags:
- Their story changes: As you discuss different treatment options, if they tend to change their mind easily, or agree with whatever you say, consider this a red flag. A confident, experienced surgeon will possess strong, unwavering opinions.
- Your gut tells you "no": Trust your gut. If you just don't feel that the doctor is the right fit, trust that and move on. On the other hand, if you feel they are the perfect specialist for you, trust that feeling.